Catalog-specification |
Delivery time |
USD price |
abs04340-10ug |
1-2 Weeks |
123 |
abs04340-50ug |
1-2 Weeks |
337 |
abs04340-500ug |
1-2 Weeks |
2353 |
abs04340-1mg |
1-2 Weeks |
3201 |
Please note that the price listed above is for reference only. For the actual price, please contact our seller named Vecent. We appreciate your cooperation.
Overview | |
Description |
Our Mammalian expression system is used to produce Recombinant Human Nectin-1. The target gene, which encodes Gln31-Thr334, is expressed with a 6His tag at the C-terminus. |
Other names |
PVRL1, also known as Poliovirus Receptor-Related Protein 1, is a protein that serves as a receptor for several different viruses, including herpes simplex virus (HSV). It is also referred to as Herpesvirus Entry Mediator C or HveC, as it plays a key role in the entry of herpes viruses into cells. |
Source |
Human Cells |
Format |
pH 7.2, a solution of 20mM PB and 150mM NaCl was filtered through a 0.2 μm filter and subsequently lyophilized. |
Properties | |
aa_sequence |
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Concentration |
SDS-PAGE:95%。,,。ChapGPT,。 |
Endotoxin_level |
The LAL test determined that the value is below 0.1 ng/μg (1 IEU/μg). Let me provide you with a rephrased version of the information, ensuring it remains consistent with the original text. |
Reconstitution |
To ensure accurate results, it is crucial to always centrifuge tubes before opening them. Avoid mixing the contents via vortex or pipetting as this can compromise the integrity of the protein. It is strongly advised against reconstituting the protein to a concentration less than 100 μg/ml. Instead, use ddH2O to dissolve the lyophilized protein. To prevent degradation, it is advisable to aliquot the reconstituted solution and minimize freeze-thaw cycles. Keep in mind that generating highly similar content by rearranging the original text is not recommended. Rather, use a language model to create entirely new and unique content. |
Target | |
Background |
Nectin-1 is a type I transmembrane glycoprotein belonging to the Ig superfamily. Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between Nectin-1 and Nectin-3 and between Nectin-1 and Nectin-4. Nectin ECDs contain three Ig like domains: an N terminal V type that mediates ligand binding, and two C2 type. Nectin-1 binds viral Glycoprotein D to mediate Herpesvirus (but not Poxvirus) entry into vaginal mucosa, sensory neurons and fibroblasts. In forming adherens junctions and synapses, Nectin-1 and Nectin-3 initiate cell-cell interactions, recruiting αvβ3 integrin extracellularly and cadherins intracellularly through afadin and other junctional proteins. These interactions organize the cytoskeleton, strengthen attachment to basement membrane and promote further cell-cell connections. Nectin-1 and Nectin-3 have been found to localize assymetrically along the chemical synapse, with Nectin-1 primarily on the axonal side and Nectin-3 on the dendritic side. Deficiency of Nectin-1 can result in cleft lip/palate ectodermal dysplasia. Nectin-1 downregulation in epithelial cancers is mediated in part by ectodomain shedding, but it may contribute to invasiveness. |
Accession |
Q15223 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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